急性颅脑伤早期脑脊液中血管加压素含量变化及意义的研究  

The vasopressin change and significancein CSF after head injured cats

作　　者：刘子生[1] 路长林[1] 王成海[1] 朱诚[1] 张洪俊[1] 冯红燕[1] 

机构地区：[1]济南军医总医院,第二军医大学

出　　处：《中华实验外科杂志》1995年第2期119-120,共2页Chinese Journal of Experimental Surgery

摘　　要：３２只雄性猫随机分为４组，以自由落体法致动物局限性脑挫裂伤。研究表明，颅脑伤后脑脊液中ＶＰ含量显著升高，脑含水量明显增加，颅内压升高；脑室内注入ＶＰ后脑含水量进一步增加，颅内压显著升高；脑室注入ＶＰ抗血清可控制颅内压升高，减轻脑水肿。提示ＶＰ参与急性颅脑伤的发病过程，脑脊液中ＶＰ含量过份升高可加重脑水肿与继发性脑损伤。Tmirty two male cats were randomly di-vided into four groups :(1) control group(n=8);(2)head-injured group(n=8);(3)VPgroup(n=8);(4) VP antibody group(n=8). Mean CSF VP levels of control animals was 68. 04 82. 08pg/ml, mean VP levels ofhead-injured cats increased to 155. 15 ± 68.58pg/ml(P<0.01).The Experimental resultsalso showed VP mav elevate ICP and increasebrain water content significantly,and that VPantibody may control ICP and alleviate brainedema effectively,It is suggested that VP maybe related to second brain damage. The macha-nism may be central VP causes an increase inedema by enhancing an already increased cap-illary water permeability.

关 键 词：颅脑损伤 血管加压素 颅内压 脑水肿 脑脊液 

分 类 号：R651.150.2[医药卫生—外科学]