山茱萸总甙抑制免疫的体内效应及其对移植心脏存活的延长  

IN VIVO IMMUNOSUPPRESSIVE EFFECT OF CORNUS OFFICINALIS GLYCOSIDES AND THEIR ACTIVITY ON PROLONGATING THE SURVIVAL OF TRANSPLANTATED MICE HEARTS

作　　者：赵武述[1] 李洁[1] 张玉琴[1] 丛笑[1] 赵世萍[2] 薛智[2] 

机构地区：[1]中日友好临床医学研究所免疫室,北京100029 [2]中日友好临床医学研究所药物药理室,北京100029

出　　处：《中华微生物学和免疫学杂志》1995年第5期325-327,共3页Chinese Journal of Microbiology and Immunology

摘　　要：腹腔注射山茱萸总甙(COG)50mg/kg·d×5和100mg/kg·d×5,小鼠淋巴细胞产生白细胞介素2(IL—2),分别由2.28±0.48U/ml下降为1.65±0.29U/ml和0.90±0.20U/ml。小鼠的MLR也因预先注射COG而显著下降。小鼠移植心脏存活时间,在COG治疗组由9.2±1.2天延长到17.4±6.7天,而且COG可在环孢霉素A(CsA)10mg/kg·d×4基础上,由15.0±1.6天延长到19.0±3.2天。After intraperitoneal injection of Cornus officinalis glycosides (COG) into mouse with a dose of 50mg/kg.dX5, LPS-induced lymphocyte blasts significantly decreased. The interleukin 2(IL-2) levels produced by mouse splenic lymphocytes in COG 50mg/kg-dX5 and 100mg/kg-dX5 groups,declined from 2. 28+0.48U/ml to 1. 65+0. 29U/ml and to 0.90+0.20U/ml,respectively. Mouse mixed lymphocytes reaction (MLR) were suppressed owing to preliminary administration of COG. The survival span of transplantated mice hearts (BALB/c-NIH mouse) prolongated from 9. 2+ 1. 2 days to 17. 4+6. 7 days in treated group with COG 400mg/kg.d X16. Furthermore,based upon administration of Cyclosporin A(CsA) l0mg/kg.d X 4,COG the survival span prolongated from 15.0+l.6 days to 19. 0 +3.2 days.

关 键 词：山茱萸 总甙 免疫抑制 移植 移植心脏 

分 类 号：R392.4[医药卫生—免疫学]