大鼠佝偻病模型和血钙浓度与骨病理参数的量效关系  

Rickets Model of Rat and Dose-effect relationship between the Serum Level of Calcium and the Parameters of Bone Pathology

作　　者：朱列伟[1] 周丽君[1] 金丕焕[1] 周森麟[1] 李国平[1] 朱畅宁[1] 

机构地区：[1]上海医科大学儿科医院,上海医科大学公共卫生学院

出　　处：《中华物理医学杂志》1995年第3期135-138,共4页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：就钙剂疗效的评定，在大鼠复制了人的佝楼病。并观察到该模型能在不同生物活性的钙剂作用下，产生不同程度的病理改变。为使这些变化能用数学方式阐述，将Ｘ线征像进行了分级定性，骨组织形态进行了体视学测算。在量效关系分析中，骨长、骨长与骺径比，骺板软骨细胞体积密度，骨干体积密度与血钙浓度的复相关，及系数间的两两简单相关均具有高度的统计学意义。在逐步回归中Ｐ＝０．０５时，骨干体积密度和骨长与骺径比与血钙浓度在偏相关具有统计学意义，Ｒ２为０．７２９０。In order to evaluate the efficacy of calcium therapy, we replicate the human rickets at rat, and with different biological activity.In order that make these changes expressed by mathematical pattern,the Tadiologic signs were graded and images of bone tissue were measured with stereometry.In dose-effect analysis, there existed multiple correlation among the variables, i.e.the length of bone,the ratio between the length of bone and the diameter of epiphysis, the volume density of epiphyseal catilage cells, the volume density of bone shaft and the serum level of calcium, and all were highly significant statisticallg.In the analysis of stepwise regression,when Plevel=0.05,the partial correlation of the volume density of the bone,the ratio between the length of the bone with the diameter of the epiphysis and the serum level of calecim,was significant statistically(R-square is 0. 7290).

关 键 词：佝偻病 图像分析 骨 动物模型 血钙浓度 

分 类 号：R591.44[医药卫生—内科学]