神经节苷脂GM_1促进挤压伤坐骨神经再生  

GANGLIOSIDE PROMOTES THE REGENERATION OF CRUSHED RAT SCIATIC NERVES

作　　者：王民生[1] 陈中伟[1] 张光健[1] 陈峥嵘[1] 

机构地区：[1]上海医科大学中山医院骨科

出　　处：《中华显微外科杂志》1995年第3期205-207,共3页Chinese Journal of Microsurgery

摘　　要：大鼠坐骨神经挤压伤后，局部应用神经节苷脂ＧＭ＿１在神经再生中的作用进行研究。选用３０只大白鼠分为６组，每组各５只，双侧１０条坐骨神经。１、２、３为对照组，４、５、６为ＧＭ＿１治疗组，观察期分别为１２、２８和５６天。结果显示，神经节昔脂ＧＭ＿１治疗可使损伤后１２天时再生有髓神经纤维计数增加，损伤后２８天和５６天时再生有髓神经纤维直径增粗，此外尚可使运动神经传导速度加快。提示神经节苷脂ＧＭ＿１可促进轴突发芽，再生神经纤维发育成熟和神经功能恢复。AbstractThe effect of topically used ganglioside(GM_1)onthe regeneration of crushed sciatic nerve was studied in30 rats.The sciatic nerves were crushed with a specif-ically made forceps and a 3mm wide crush injury wascreated. Then 2.1 ul normal saline for the control or2.l ul GM_1(10μg) for GM_1-treated groups was in-jected into the crush site. The follow-up interval was12 , 28 and 56 days respectively; The results showedthat there were more regenerative myelinated fiber(RMF)in GM_1-treated group at 12 days compared tothe control one, The average diarneter of RMF of GM_1-treated groups was larger than than of control oneat 28 and 56 days respectively, In addition,faster motor nerve conductive velocity was demonstrate in GM_1-treated groups,especially at 56 days. These resultsindicate that GM_1 can promote nerve regeneration incrushed rat sciatic verves.

关 键 词：神经节苷脂 神经再生 神经挤压伤 

分 类 号：R651.305[医药卫生—外科学]