甘丙素在急性心肌梗塞发病中的意义  

Clinical significance of galanin in the pathogenesis of acute myocardial infarction

作　　者：石湘芸[1] 赵云涛[1] 宫长宁[1] 田青[1] 赵东[1] 丁殿勋[1] 聂智群[1] 徐洪涛[1] 费宇行[1] 汤健[1] 唐朝枢[1] 

机构地区：[1]解放军海军总医院,北京医科大学心肺内分泌研究室

出　　处：《中华心血管病杂志》1995年第3期179-181,共3页Chinese Journal of Cardiology

摘　　要：测定３１例急性心肌梗塞（ＡＭＩ）患者血浆甘丙素（ＧＡＬ）的放免活性，结果示ＡＭＩ患者急性期各次血浆ＧＡＬ水平明显高于对照组，梗塞范围大则升高更显著，ＧＡＬ与内皮素（ＥＴ）、血糖水平均呈正相关。实验性心肌梗塞大鼠血浆ＧＡＬ、血清肌酸激酶ＣＫ同功酶、丙二醛含量亦明显高于对照大鼠，用ＧＡＬ抗血清治疗心肌梗塞大鼠，减少坏死面积４５．４％和缩小了梗塞范围４７．１％，亦明显降低了血浆ＧＡＬ水平，抑制血清酶活性，提示早期阻断ＧＡＬ的生物学效应，对防治ＡＭＩ有重要意义。Abstract The level of plasma galanin (GAL) was studied in 31 cases of acute myocardial infarction (ANI) by radioimmunoassay. The results showed that the plasma GAL levels in the AMI group at different periods were all significantly higher than those in the control group (P<0. 01-0. 001); furthermore in AMI with large infarction size,plasma GAL level increased more obviously. Plasma GAL level positively correlated with plasma endothelin (ET) and blood sugar levels.The effect of GAL-antiserum on myocardial infarction (MI) was investigated on infarct model produced by ligature of the left anterior decending coronary artery of rats.The results showed that plasma levels of GAL, CK, CK-MB and MDA elevated significantly in rats with MI, and GAL-antiserum administration reduced the infarct size by 47.1%, decreased the plasma levels of CK , CK-MB and MDA. It suggests that GAL is an important factor which might be related to the pathogenesis of MI.

关 键 词：心肌梗塞 甘丙素类 病因 病理 

分 类 号：R542.220.2[医药卫生—心血管疾病]