盐敏感性高血压对盐负荷呈现“低减型”肾排钠反应者的Ouabain抵抗现象  

An ouabain-resistant phenomenon in salt-sensitive hypertensives with decreased renal sodium excretion after saline loading

作　　者：李玉明[1] 刘治全[1] 杨鼎颐[1] 郭建芬 牟建军[1] 王哲训[1] 

机构地区：[1]西安医科大学第一附属医院心内科

出　　处：《中华心血管病杂志》1995年第5期329-331,共3页Chinese Journal of Cardiology

基　　金：自然科学基金

摘　　要：为探讨盐敏感性高血压者盐负荷后“低减型”肾排钠反应是否与钠泵的Ｏｕａｂａｉｎ抵抗有关，我们观察了２９例盐敏感性高血压患者在基础状态及盐负荷后的肾排钠反应类型、血浆内源性类洋地黄物质（ＥＤＬＳ）水平、外周淋巴细胞钠泵数量与活性等的改变，以及不同浓度Ｏｕａｂａｉｎ对培养淋巴细胞钠泵活性的影响。２９例中有９例于盐负荷后呈“低减型”肾排钠反应，后者血浆ＥＤＬＳ水平明显升高，但淋巴细胞８６Ｒｂ摄入率及Ｏｕａｂａｉｎ游离结合位点数目并不减少；经体外培养在一定浓度Ｏｕａｂａｉｎ基质中，“低减型”肾排钠反应者的淋巴细胞钠泵８６Ｒｂ摄入率无相应减少。提示对盐负荷呈“低减型”肾排钠反应的盐敏感者钠泵存在Ｏｕａｂａｉｎ抵抗现象。Abstract To identify if the decreased type of renal sodium excretion after saline loading in salt-sensitive hypertensives (SS) was related to ouabain-resistance, an acute saline loading test was performed in 29 cases of SS and the renal sodium excretion type, plasma endogenous digoxin-like substances (EDLS),peripheral lymphocyte Na￣+,K￣+-ATPase activity and quantity at basal and after saline loading and the effect of difference concentration of ouabain on Na￣+ , K￣+-ATPase activity of the cultured lymphocytes were measured.Of the 29 salt-sensitive hypertensives, 9 cases expressed as decreased type of renal sodium excretion after saline loading. In the lat ter group of types. the levels of plasma EDLS signifi cantly increased but the lymphocyte (86)￣Rb uptake rate did not decrease before and after saline loading and 3￣H-ouabain binding sites did not reduce too: the cultured lymphocyte(86)￣Rb uptake rate was not suppressed by different ouabain concentration in medium.These data suggested that the ouabain-resistant phenomenon existed only in the SS with the decreased renal sodium excretion after saline loading.

关 键 词：盐敏感性 高血压 肾脏排钠反应 钠泵 

分 类 号：R544.1[医药卫生—心血管疾病]