西双版纳傣族及上海汉族群体HLA－DR2相关的DR／DQ单倍型分析  

HETEROGENEITY OF DR2 HAPLOTYPES(DRB1,DRB5,DQA1,DQB1)IN DAI MINORITY AND HAN ANTIONALITY POPULATION IN CHINA

作　　者：范丽安[1] 杨珏琴[1] 姚芳娟[1] 董建中[1] 许玲娣[1] 陈仁彪[2] M Sirkong R Vongrathna P Longta S Lekmak D Chandanayingyong A Smith J Hansen 

机构地区：[1]上海第二医科大学、上海免疫学研究所免疫遗传学研究室 [2]上海第二医科大学、上海免疫学研究所医学遗传教研室 [3]泰国马海同大学 [4]美国弗莱特赫钦森癌症研究中心

出　　处：《中华医学遗传学杂志》1995年第3期134-137,共4页Chinese Journal of Medical Genetics

摘　　要：对４４名西双版纳傣族和９名上海地区汉族ＤＫ２阳性个体进行了与其相关的ＤＲ／ＤＱ单倍型组合的分析。傣族群体中ＤＲＢＩ－ＤＲ２亚型分布以＊１６０２与＊１５０２为最常见，其等位基因频率分别为４３．６％与，４０．０％和汉族群体中以＊１５０１为主明显不同。傣族群体中共检出１０种与ＤＲ２相关联的ＤＲ／ＤＱ单倍型；最常见的是ＤＲＢ１＊１６０２、ＤＲＢ５＊０１０１、ＤＱＡ１＊０１０２、ＤＱＢ１＊０５０２（３４．５％）与汉族及其他群体明显不同，本研究表明傣族不仅具有高频率的ＤＲ２，而且与ＤＲ２相关联的ＤＲＢ１、ＤＲＢ５、ＤＱＡ１、ＤＱＢ１单倍型组合有其独特性。We have characterized the DRB1,DRB5,DQA1 and DQB1 alleles of 44 unrelated DR2 positive individuals from the Dai minority population of Xishuangbanna and of 9 DR2 positive individiuals from Han population.The most frequent DR2-associated alleles were DRB1*1602(43.6%)and DRB1*1502(40.0%)in Dai population and DRB1*1501 in Han population.A total of ten different DR2 associated DR/DQ haplotypes were identified in Dai population;the most common DR2 haplotypes in Dai population were DRB1*1602,DRB5* 0102,DQA1* 0101,DQB1*0502(34.5%)and DRB1*1502,DRB5*0102,DQA1*0101,DQB1*0501( 18.2%).This study indicates that the Dai minority population has a very high frequency of DR2 with multiple unusual DRB1,DRB5,DQA1,DQB1 haplotypes.

关 键 词：傣族 汉族 DR2-单倍型 DRB1＊1504 人类白细胞抗原 

分 类 号：Q343.12[生物学—遗传学] Q347