新生儿的肺功能测定  

Pulinonary function detection in newborn infants

作　　者：刘玺诚[1] 江载芳[1] 袁晓霞[1] 李跃进 麦笑梅 李民勖 

机构地区：[1]北京儿童医院

出　　处：《中华医学杂志》1995年第8期489-493,共5页National Medical Journal of China

摘　　要：为了解新生儿正常肺功能的各项指标，以开展对新生儿肺功能的研究，作者应用潮气呼吸流速－容量曲线替代最大呼气流速－容量曲线、被动呼气流速容量技术测定呼吸系统阻力和顺应性以及开放式氮气洗出法测定功能残气量等无创、无需小儿主动配合的新技术对，１２０例足月新生儿和２０例早产儿进行了肺功能测定。测定项目有潮气呼吸状态下的通气功能；潮气流速－容量环的形状，呼吸动力学指标：呼吸系统阻力、顺应性以及功能残气量。将足月新生儿分为～１天、～３天、～７天、～１４天、～２１天、～２８天组，分别进行肺功能指标测定，建立参考值。新生儿肺功能在男女性别之间差异无显著意义（Ｐ＞０．０５）。肺功能随着日龄增加变化显著，１４０例新生儿的潮气量，每分通气量，潮气呼气峰流速，功能残气量，呼吸系统静态顺应性，被动呼气时间常数与日龄，身长及体重呈正相关（ｒ＞０．６，Ｐ＜０．００１）。早产儿的通气功能、功能残气量及呼吸系统静态顺应性显著低于足月新生儿（Ｐ＜０．０５～０．００１），而呼吸系统阻力显著高于足月新生儿（Ｐ＜０．００１）。提示通气功能可以作为判定气管和肺成熟度的可靠指标。新生儿肺功能检查是鉴定呼吸系统成熟度、揭示其生长发育规律以及研究呼吸系统疾病?e studied 120 full-term newborn infants and 20pre-term infants by means of recording tidal breathingflow volume loops, passive flow volume technique andopen circuit N2 washout technique. In the preterm in-fants, ventilatory function, FRC and Crs were lowerthan those in full-term infants, and Rrs were higherthan those of full-term infants. TV, MV and PTEFwere positively corelated with age (day) , weight andheight FRC , Crs and Trs were positively corelated withweight and height. TBFV loop in normal newborn in-fants did not show round or ellipse curve. The curve ofexpiration rose quickly, the position of expiration peakclosed to the front, and decending line of expirationwas relatively tilting. RR, Ti/Ttot, VPF, TPF,PF25, PTEF/TV, MEIMI, FRCkg, Crskg, sCrs,Rrs and sRrs were valuble indices in neonatal pul-monary function test. The results of our study are im-portant in the estabtishment of normal values of pul-monary function indices fer newborn infants in China.

关 键 词：早产儿 新生儿 肺功能 呼吸功能试验 性别 

分 类 号：R722[医药卫生—儿科]