安徽省农村0～3岁儿童脊髓灰质炎中和抗体水平调查  

Surveillance of Levels of Neutralizing Antibodies agalnst Poliovirus among Children Aged 0-3 in Rural Areas of Anhui Proviuce

作　　者：沈永刚[1] 赵月萍[1] 刘丹青[1] 陈晓琴[1] 戴振威[1] 丁一新[1] 何维宽[1] 刘宏杰[1] 余文周[1] 张莲芝[1] 

机构地区：[1]安徽省卫生防疫站

出　　处：《中华预防医学杂志》1995年第6期335-338,共4页Chinese Journal of Preventive Medicine

摘　　要：１９９３年９月，在１８个县随机抽取１７５５名０～３岁儿童，开展脊髓灰质炎免疫水平调查，以指导今后全省消灭脊髓灰质炎工作。结果：１、２、３型中和抗体的几何平均滴度（ＧＭＴ）和阳性率分别为：５２４．８０和９６．９８％，３２３．５９和９６．０１％，４３６．５０和９６．１８％。各县的抗体水平都比较高。各年龄组和不同性别的ＧＭＴ和阳性率的差异不显著，服苗次数间差异十分显著。被查儿童平均服苗４次，在一定服苗次数范围内，服苗次数与ＣＭＴ成正比。全程服苗的儿童阳性率达到９５％以上。个别乡村存在免疫薄弱现象。结果说明全省农村地区儿童的脊髓灰质炎免疫水平较高。evels of neutralizing antibodies against poliovirus(PV)In 1755 children aged 0-3 sampled ran- domly from 18 counties in Anhui Province were deterrnined in September,1993.Results showed the positive rates and geornetric mean titer(GMT)of netitralizing antiliodies against PV type 1,2 and 3 were 96.98%,96.01%and 96. 18%, and 524.80,323.59 and 436.50,respectively. Immune level of children was considerable high in each county sampled.No significant difference was found among dif- ferent age groups and between boys and girls in positive rates and GMT of polioantibodies,but there was significant difference in them between children administered varied doses of oral poIlo vaccine(OPV). Children investigated took four doses of OPV in average,and their GMT was in proportion to the dose they tcok.Positive rate of PV antibodies was nore than 95%in children who finished the full course of OPV immunization,There were very few townships or villages with a low coverage of OPV immuniza-tion in children. It indicated polio immune status was in a higher level in the Province.

关 键 词：脊髓灰质炎 抗体 儿童 

分 类 号：R512.403[医药卫生—内科学]