烧伤、冲击伤和烧冲复合伤大鼠肺微血管超微结构病变  

Ultrastructural changes in pulmonary microvascular damage in rats inflicted with burn,blast and combined burn-blast injury

作　　者：郑怀恩[1] 程天民[1] 林远[1] 古德全[1] 阎国和[1] 李爱莲[2] 

机构地区：[1]第三军医大学防原医学教研室,重庆630038 [2]第三军医大学病理学教研室,重庆630038

出　　处：《中华整形烧伤外科杂志》1995年第6期425-429,482,共5页

摘　　要：为进一步研究烧冲复合伤时肺脏病变的特点,我们制备了大鼠重度冲击伤、15%Ⅲ度烧伤和烧冲复合伤模型,对肺脏微血管的病理变化进行光镜、电镜观察和超微结构定量分析。结果表明,烧伤时肺脏病变主要是肺毛细血管超微结构发生损伤,病变程度较轻。冲击伤和烧冲复合伤时肺微血管损伤均很明显,尤以后者为重,表现为肺水肿增加,血管病变突出,包括小动脉壁结构松散,毛细血管内皮细胞高度肿胀,管腔变窄,血管内大量中性粒细胞聚集等,且病变恢复较慢。提示:上述伤情时微血管损伤是肺脏病变中的主要变化,在防治中应予特别注意。The pathological changes in pulmonary microvasculature in rats inflicted with overpressure blast,15 % third degree burns and combined burn-blast injury,respec- tively,were studied with electron microscopy and ultrastructural morphometry.Results indicated that the pathological changes in pulmonary microvasculature in 15% third de- gree burns were slight,and mainly restricted to-ultrastructural level.While in severe blast and burn-blast injuries,the damage of pulmonary microvasculature including en- dothelial swelling and regeneration and dispersal of arteriole wall structure,was promi- nent.These changes form the basts of pulmonary hemorrhage and edema.Apart from vessel structural damages,arteriole constriction and capillary closure were also observed during 2 to 4 h postinjury.The vessel damage and dysfunetion were more severe in com- bined injury than in blast injury alone.The mechanisms needed to be studied further.

关 键 词：冲击伤 肺超微结构病变 烧伤 复合伤 

分 类 号：R642[医药卫生—外科学]