双重滤过血浆分离置换法的应用及疗效  

APPLICATION OF DOUBLE FIL TRATION PLASMAPHERESIS AND PRELIMINARY REPORT OF ITS THERAPEUTIC ETTECTIVENESS

作　　者：张兆权[1] 张凌[1] 连祖民[1] 赵丽 杜学海 

机构地区：[1]山东胜利油田中心医院

出　　处：《中日友好医院学报》1995年第3期137-140,共4页Journal of China-Japan Friendship Hospital

摘　　要：应用双重滤过血浆分离置换法（ＤＦＰＰ）治疗为数尚少的系统性红斑狼疮（ＳＬＥ）、多发性骨髓瘤（ＭＭ）和高脂血症（ＨＬ）。结果显示：ＤＦＰＰ对清除血液中大分子量蛋白形成的病因物质如与ＳＬＥ发病有关的抗体、ＨＬ患者的胆固醇（ＣＨＯ）、甘油三酯（ＴＧ）和载脂蛋白Ｂ（ＡＰＯＢ）等有较好的作用，同时可使ＭＭ患者的血尿酸下降和骨痛等症状明显减轻。而且ＤＦＰＰ的补液量少，减少了副作用，表明ＤＦＰＰ比标准血浆置换（ＰＥ）有较大的优点。A newer blood purification tedinique DFPP to treat a fewer patients with systemic lupus erythematosus(SLE),multiple myeloma(MM)and hyperlipidemia(HL)was reported. The results showed that DFPP had better effect on removal of pathogenic materials which were formed from middle-large molecular proteins in blood ,such as autoantibodies associated with pathogenesis of SLE and apolipoprotein B(APOB)of hyperlipemia(HL)patients.DFPP can also decrease serum uric acid concentration and relieved bone pain of MM patients signifi-cantly,Because of less substitution solution,there are less side effects in DFPP,Thereafter,it is suggested that DFPP had more advantages over standard plasma exchange(PE).

关 键 词：双重滤过 血浆分离置换法 临床应用 

分 类 号：R459.5[医药卫生—治疗学]