腹水良恶性细胞核仁组成区定量研究  

MORPHOMETRIC ANALYSIS OF SILVER-STAINED NUCLEOLAR ORGANIZER REGIONS IN BENIGN AND MALIGNANT ASCITES

作　　者：张世能[1] 袁世珍[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院消化内科

出　　处：《中山医科大学学报》1995年第3期26-29,共4页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：使用胶质银染色技术，对２８例良性腹水和２６例恶性腹水进行核仁组成区（ＡｇＮＯＲｓ）形态定量研究。结果表明：良性腹水间皮细胞与恶性腹水癌细胞二者在ＡｇＮＯＲｓ数目、形态、大小及核内分布方面均存在显著差异。另外，对５例临床上疑诊恶性腹水而常规脱落细胞学（ＨＥ）染色阴性或未肯定者进行上述定量分析，确定腹水良恶性质，结果与组织病理学诊断相一致。提示该技术在一定程度上可弥补常规脱落细胞形态学之不足。he purpose of this study was to investigate the diagnostic value of silver-stained nucle- olar organizer regions (AgNORs ) in benign and malignant ascites. AgNORs were studied with quantitative methods in 54 cases , including benign ascites ( 28 ) and malignant ascites (26). The number ,shape ,size and distribution of AgNORs were counted and analysed. Use of the similar staining method was attemped in five additional patients. The results showed : the number of AgNORs was significantly higher incarcinoma cells (6. 19 ± l. 47)than that in mesothelial cells(2. 47±0. 44,p<0. 01). There are also significant differences in morpholo- gy ,size and distribution of AgNORs between them. All the results of AgNORs of additional patients were compatible with the histologic and clinical follow up. These results suggest that the four quantitative parameters of AgNORs might be useful for the differential diagnosis of malignant ascites and benign ascites.

关 键 词：核仁组成区 病理学 腹水 诊断 

分 类 号：R442.5[医药卫生—诊断学]