薤白对大鼠血清抗坏血酸自由基和血清发光的影响  

Effects of Allium macrostemon on Rat Serum Ascorbate Free Radical and Serum Chemiluminescence

作　　者：李向红[1] 段绍瑾[1] 顾丽贞[1] 王爱红 刁伟珍 

机构地区：[1]中国中医研究院广安门医院,北京100053

出　　处：《中药材》1995年第10期521-523,共3页Journal of Chinese Medicinal Materials

摘　　要：本文采用电子自旋共振和化学发光技术,研究了薤白鲜汁对大鼠血清抗坏血酸自由基和血清发光的影响。结果表明,薤白鲜汁能使血清抗坏血酸自由基自旋浓度降低,呈量效关系,和抗氧化剂谷光甘肽情况类同。薤白汁使血清发光最大值和积分值均显著降低,谷光甘肽使血清发光最大值显著降低、积分值呈升高趋势。提示薤白汁和谷光甘肽对血清发光的作用机理可能不同。进一步实验的结果显示薤白鲜汁和羟自由基清除剂甘露醇对血清发光特征的作用情况类同。In this experiment, the effects of Xiebai (Bulbs of Allium macrostemon) juice (XJ) on rat serum ascorbate free radical (A) and serum chemiluminescence were studied with electron spin resonance (ESR) and chemiluminescence technique. The results showed that XJ could decrease the spin concentration of serum A with dose-dependent responses like glutathione (GSH); and that XJ decreased serum chemiluminescent maxi-mum response (M) and integrated response (IR) significantly, whereas GSH decreased MR significantly and increased IR to some extant, indicating that the effect mechanism of XJ on serum chemiluminescence is different from that of GSH. Further experiment results showed that XJ have similar influence on serum chemiluminescence to mannitol.

关 键 词：薤白 抗坏血酸自由基 抗氧化剂 大鼠 血清发光 

分 类 号：R282.710.5[医药卫生—中药学] R285.5[医药卫生—中医学]