大鼠亚临床维生素A缺乏与缺铁性贫血  

RELATIONSHIP BETWEEN SUBCLINICALVITAMIN A DEFI-CIENCY AND IRON-DEFICIENCY ANEMIA IN THE RATS

作　　者：符州 黎海芪 郑惠连 

出　　处：《重庆医科大学学报》1995年第3期180-182,179,共4页Journal of Chongqing Medical University

摘　　要：取Ｗｉｓｔａｒ年轻雄性大鼠２４小只分成实验组和对照组，分别饲维生素Ａ（ＶＡ）缺乏和正常对照食物，从而建立亚临床ＶＡ缺乏大鼠动物模型。实验各阶段测定有关指标，总实验期８０天。结果表明：亚临床ＶＡ缺乏对生长发育无明显影响，也无临床症状，但可影响造血功能，造成①与缺铁性贫血类似的血液学及生化改变②贮存铁释放障碍致肝脾铁累积。该结果为治疗缺铁性贫血提供了依据，对临床出现贫血单用铁剂效果不好者加用ＶＡ；则可能收到满意的效果。wenty-four male rats were divided randomly into the experimental and control groups,fedwith vitamin Adeficient diet and normal diet. respectively。 Total expetiment period was 80 days。The resulrs showed that subclinical Vitamin A deficiency had rarely influenced the growth anddevelopment of rats,but affected the hematopoietic function of the experimental rats as follows:1)Similar changes like lron- deficient anemia happened in hematological indexes and serumbiochemical parameters and 2) transferrin synthesis decreased in Vitamin A- deficient group,re-sulting in Iron accumulation in liver and spleen,reducing Iron transportation to the bOne mar-row, stimulating bone marrow proliferation。Based on our study,it is supported that Vitamin A is somewhat related with mechanism ofiron metabolism,When the response to treatment with iron alone is not satisfied, Vitamin AShould be added with the iron,and anemia would be greatly improved。

关 键 词：维生素A缺乏 缺铁性贫血 大鼠 造血功能 

分 类 号：R591.410.2[医药卫生—内科学] R556.302[医药卫生—临床医学]