双氯芬酸钠控释片剂的初步研究  

PRELIMINARY STUDY ON CONTROLLED RELEASE TABLETS OF DICLOFENAC SODIUM

作　　者：陈晓东[1] 徐惠南[1] 

机构地区：[1]上海医科大学药剂教研室,上海中西药业股份有限公司技术中心

出　　处：《中国医药工业杂志》1995年第8期343-347,共5页Chinese Journal of Pharmaceuticals

摘　　要：采用正交设计，以一种进口缓释片为对照，研制了双氯芬酸钠控释包衣片剂。其体外溶出符合零级速率方程，释药速率力３ｍｇ／ｈ，与对照制剂相当，其释药受ｐＨ及转速的影响，衣膜增重百分比的倒数与释药速率成较好的线性关系（ｒ＝０．９９８８），批内及批间释药重现性良好。On the basis of the imported sustained-release tablets TAKS,controlled-release tablets of diclofenac sodium (CRD) were developed by means of orthogonal design.The dissolutfon of CRD was best described by zeroorder kinetic equation with release rate of 3 mg/h,and there was no significant difference between CRD and TAKS.Release rate of CRD was affected by PH value of delivery medium and rotation speed-There was linear relationship between the release rate and the reciprocal of percentage weight increase of film coating (r=0.9988).There appeared to be insignificant difference within and between three batches of CRD.

关 键 词：双氯芬酸钠 片剂 膜控法 

分 类 号：R944.4[医药卫生—药剂学]