乌苯美司体外对人单核细胞功能的活化作用  

ACTIVITY OF UBENIMEX ON FUNCTIONS OF HUMAN MONOCYTES IN VITRO

作　　者：沈炜明[1] 强文安[1] 杜敏琼[1] 刘锦荣[1] 宗黎琼[1] 陆瑶华[1] 

机构地区：[1]上海市第六人民医院临床药学研究室,华西医科大学,上海医药工业研究院

出　　处：《中国医药工业杂志》1995年第9期397-400,共4页Chinese Journal of Pharmaceuticals

摘　　要：观察了国产乌苯美司（乌比美克）体外对人单核细胞功能的影响：①０．０１～１００μｇ／ｍｌ乌苯美司能直接诱导人单核细胞生成ＩＬ－１；②经０．１μｇ／ｍｌ乌苯美司作用４ｈ后，人单核细胞即开始分泌ＩＬ－１，２４ｈ达到高峰，以后逐渐下降；③经１０～１００μｇ／ｍｌ乌苯美司预处理，单核细胞可促进ＮＫ细胞活性，而经０．０１～０．１μｇ／ｍｌ乌苯美司处理，单核细胞则抑制ＮＫ细胞活性．The effets of home-made ubenimex on the function of human monocytes in vitro have been studied. Over a wide range of concentrations(0.01～100μg/ml),1 could directly induce IL-1 synthesis and secretion. After 4 h exposure of human monocytes to 1 at 0.1μg/ml, the monocytes began to promote the production of IL-1, and the effect reached the peak level of secretion at 24h, and then declined gradually. The effect of monocytes on NK activity was boosted when 10～100μg/ml of 1 were used for pretreatment of monocytes, while the influence of monocytes was iuhibited when 0.01～0. 1μg /ml of 1 were used.

关 键 词：乌苯美司 单核细胞 NK细胞 白细胞介素1 

分 类 号：R963[医药卫生—微生物与生化药学] R967[医药卫生—药理学]