吡哌酸片的电荷转移反应分光光度测定  

SPECTROPHOTOMETRIC DETERMINATION OF PIPEMIDIC ACID TABLET WITH CHARGE TRANSFER REACTION METHOD

作　　者：张昇晖 冯建章[1] 童沈阳[1] 

机构地区：[1]北京大学化学系,湖北民族学院

出　　处：《中国医药工业杂志》1995年第9期404-406,共3页Chinese Journal of Pharmaceuticals

摘　　要：研究了吡哌酸与四氯苯醌间的荷移反应。两者在硼砂缓冲溶液中形成１：１的络合物，其 λｍａｘ为３３０．８ｎｍ，摩尔吸光系数ε＝１．６６×１０＾４，ＲＳＤ为２．２％。用于测定制剂含量，结果与药典方法一致。A new spectrophotometric method was based on a reaction of pipemidic acid(PA) by charge transfer with tetrachlorobenzoquinone in borax buffer solution. Beer’s law was obeyed in the range of 0.5～12μg/10ml of PA. The composition of PA and tetrachlorobenzoquinone complex was 1:1 with a molar absorptivity of 1.66 × 104 at 330.8nm. The RSD was 2.2% .

关 键 词：电荷转移反应 吡哌酸片 分光光度法 

分 类 号：R927.2[医药卫生—药学]