抗结核单克隆抗体治疗对小白鼠脾内结核杆菌增殖的影响  

The Effect of Mycobacterial Monoclonal Antibodies on the Multiplicationof Mycobacterium Tuberculosis in the Spleen of Mice

作　　者：匡铁吉[1] 宋萍[1] 覃振林[1] 王仲元[1] 孙淑英[1] 马淑萍[1] 王利平[1] 王薇[1] 薛建利[1] 

机构地区：[1]北京解放军309医院结核病研究室,北京市胸科医院

出　　处：《军医进修学院学报》1995年第2期92-95,共4页Academic Journal of Pla Postgraduate Medical School

摘　　要：本文就抗结核单克隆抗体治疗对小白鼠脾内结核菌增殖的影响进行了研究。发现：高剂量单抗治疗可强烈抑制小鼠脾内结核菌生长；低剂量单抗治疗对脾内结核菌的生长呈弱抑制作用。在高、低剂量之间的剂量范围内，单抗治疗刺激脾内结核菌的生长。同一单抗对不同菌株感染的小鼠治疗效果不同，病原菌感染剂量对单抗的治疗效果具有重要影响。The therapeutic effects of antimycobacterial monoclonal antibodies on the multiplication ofmycobacterium tuberculosis in the spleen of mice were Studied.It was found that high concent-ration of monoclonal antibodies could strongly inhibit the proliferation of tuberculosis bacillus inmice spleen and that low concentration of monoclonal antibodies weakly inhibited the growth oftuberculosis bacillus in mice spleen. However,when the monoclonl antibodies with aconcentrationbetween the high and the low was used in treatment,the multiplication of tuberculosis bacillusin nice spleen was obviously promoted,The therapeutic effects of the same strain of monoclonalantibodies on different strains of mycobacterium tuberculosis were different.The infected dosesof tuberculosis,bacillus also showed an important influence on the therapeutic effects of the mo-noclonal antibodies.

关 键 词：单克隆抗体 结核杆菌 免疫疗法 感染 小鼠 

分 类 号：R456[医药卫生—治疗学] R392[医药卫生—临床医学]