高压氧疗对高海拔地区大鼠肺动脉压及血清血管紧张素转换酶的影响  

EFFECT OF HYPERBARIC OXYGEN ON PULMONARY ARTERY PRESSURE AND SERUM ANGIORENSION CONVERTING ENZYME IN ALTITUDE RATS

作　　者：吴意华[1] 马清太 韩冬花[1] 史朝秀 尖措 陈华纬 胡琳[1] 

机构地区：[1]青海省高原医学科学研究所氧舱科

出　　处：《高原医学杂志》1995年第3期12-14,共3页Journal of High Altitude Medicine

摘　　要：本实验利用移居高原的Ｗｉｓｔａｒ大鼠在采用常规高压氧治疗一疗程后，用入导生理记录仪测体、肺动脉压；取血测血清血管紧张素转换酶活性。发现治疗后肺动脉平均压有非常显著下降（Ｐ＜０．０１）；血清血管紧张素转换酶活性显著增强（Ｐ＜０．０５）；提示高原地区运用高压氧疗对肺动脉高压有一定治疗作用；从血清血管紧张素转换酶活性变化中未能证实高压氧对肺组织的损伤。he direct systemic and pulmonary artery pressrue and activity of serum angiotension convertingenzyme(ACE)in Wistar rats migrated into high altitude were separately measured before and after hy-perbatic oxygen exposure( HOE.The results showed that the mean pulmonary artery pressure dropped significantly(P<0. 01)and the activity of serum ACE rose significantly (p< 0.05)afterHOE. It was indicated that hyperbaric oxygen may show therapeutic effect on pulmonary hypertensionin human. The lung tissues did not show impairment due to active altering of ACE.

关 键 词：高压氧治疗 高原 血管紧张素 转换酶 肺动脉压 

分 类 号：R459.6[医药卫生—治疗学]