米非司酮、双炔失碳酯单独或联合应用于紧急避孕的临床观察  

Clinical trial of mifepristone and anordrin for emergency contraception

作　　者：韩学军[1] 翁梨驹[1] 张力萍[1] 曾陶 肖碧莲 

机构地区：[1]北京首都医科大学附属北京朝阳医院妇产科,国家计划生育委员会科学技术研究所

出　　处：《生殖医学杂志》1995年第4期206-211,共6页Journal of Reproductive Medicine

摘　　要：为探索紧急避孕方法，对１３９名健康、月经规律的妇女在避孕失败或无保护的性生活后７２小时内就诊服药并随机分为３组：组Ⅰ（ｎ＝４６），首次口服米非司酮（息隐）２５ｍｇ，１２小时后重复１次，总量５０ｍｇ；组ⅡＩ（ｎ＝４６），首次服双炔失碳酯（Ｃ５３号）７．５ｍｇ，１２小时后重复１次，总量１５ｍｇ。组Ⅲ（ｎ＝４７），１次服息隐２５ｍｇ＋Ｃ５３号７．５ｍｇ。结果组Ⅰ、组Ⅲ无一例妊娠，避孕有效率１００％；组Ⅱ妊娠２例，接近预期妊娠数３．１６３，避孕有效率３６．７％。服药月经改变少，副反应发生率低。４５例在围排卵期同时作了激素测定及阴道超声波检查，激素变化可分为三种类型：无排卵型、排卵前后型与排卵后型。超声波所见与激素测定相符，显示米非司酮有较明显的抑制排卵或卵泡发育。结果表明，低剂量米非司酮单独服用５０ｍｇ或２５ｍｇ与双炔失碳酯７．５ｍｇ联合紧应用都可作为性生活后７２小时内的有效紧急避孕。Objectives:To study the efficacy of mifepristone and/or anordrin for emergency contraception( EC).Design:A randomized clinical trial.Setting:Outpatients clinic of Chaoyang Hospital in Beijing. Subjects:139 healthy women with history of unprotected intercourse or contraceptive failure were re-cruited from February to April 1995.All had regular mentrual cycles and attended the clinic within 72 hours after,intercourse. Methods: Women were randomly allocated into 3 groups. In group I,mifepristone 25mg was given and the same dose was repeated 12 hours later with a total dose of 50mg(n=46 ).In group II,Anordrin 7.5mg was given twice at 12 hours interval(n=46).Group III,both mifepristone 25mg and anordrin 7.5mg were given once(n=47).Women were asked to record their bleeding patterns as well as any unexpected adverse effects. The pregnancy rates were calculated by Dixon’s method according to the expected pregnancy proba-bility on specific cycle day. Serum estradiol,LH and progesterone were determined in 45 women of the 3 groups before and after treatment, and transvaginal ultrasonography were carried out at the same time. Results:The contraceptive effective rates were 100% in both group I and III,and 36.7%(2/46)in group II,which was close to the expected pregnancy 3.163.Menstruation was postponed in 7 women(15.2%)in group I.4 women(8.7%)in group II and II (23.4%)in group III.Side effects including nausea and vomiting were reported as 4.3%,15.2%.and 6.4% in the 3 groups respectively,and were not signifi-cantly different.Hormone assays showed 3 patterns of changes i.e.anovulatory,periovulatory and postovu-latory,and were confirmed by B ultrasound.Conclusion:Low dose mifepristone or in combination with anordrin given within 72 hours after unpro-tected intercourse was effective for emergency contraception.

关 键 词：米非司酮 双炔失碳酯 避孕 紧急避孕 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]