RU486药物流产与手术流产方法的可接受性比较研究  

The potential of RU 486 for medical termination of pregnancy :an acceptability and feasibility study

作　　者：孙红珠 吴尚纯 徐慧颖 肖碧莲 

机构地区：[1]国家计划生育委员会科学技术研究所,辽宁计划生育科学研究所

出　　处：《生殖医学杂志》1995年第3期138-138,共1页Journal of Reproductive Medicine

摘　　要：对药物流产及手术流产的可接受性比较结果显示，１００例停经５６天以内的健康妇女接受药物流产，一次口服ＲＵ４８６６００ｍｇ，４８～５６小时内再口服米索前列醇（ＰＧＥ１）４００μｇ，完全流产率９１．Ｏ％，不全流产率５．０％，继续妊娠率４．Ｏ％。６８例停经４２～５６天的健康妇女接受手术负压吸宫术流产，完全流产率１００．Ｏ％。选择药物流产的主要原因是痛苦少（占７５．０％），选择手术流产的主要原因是流产效果好（占４１．２％）和流产时间短（占５７．４％）。药物流产的主要问题是出血时间长（占２５．Ｏ％）和出血量多（占１１．Ｏ％）。药物组９１例完全流产者流产后出血持续时间平均为１６．１±９．Ｏ天。手术组６８例完全流产者，流产后出血持续时间平均为８．９±６．１天。iaoning Research Institute for Family Planning Objective:To compare the acceptability of medical abortion with mifepristone and that of surgical abor- tion.Design : A non-randomized comparative study of two treatment methods.Setting :A clinic in the National Research Institute for Family Planning Subjects: 168 women with gestational age of 42～56 days requesting termination were given the choice of medical abortion with RU 486 or vacuum aspiration.Intervention: For medical abortion RU486 600 mg was given on the day of admission and misoprostol 400 μg 48 hours later.Surgical abortionwas performed with vacuum aspiration.Results :A hundred women chose medical abortion,while 68 chose surgical abortion.The complete abortion rate with the medical and surgical abortion were 91%and 100%,respectively.The main reason for choosing medical abortion was less pain(75%),while those for choosing surgical abortion were high effec tiveness(41.2%)and short abortion time(57.4%).The main bad features for the medical method were prolonged bleeding(25%)and more blood loss( 11%).The mean duration of bleeding after abortion was 16.1±9.0 days,significantly longer than after the surgical abortion(8.9±6.1 days)。Conclusion :Medical abortion with RU 486 is more acceptable,the only drawback is the prolonged postabortion bleeding Further study to reduce bleeding after medical abortion is needed.

关 键 词：米非司酮 前列腺素E类 真空刮宫术 药物流产 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]