青心酮对大鼠被动吸烟胎儿宫内生长迟缓的疗效观察  

The therapeutic effect of 3,4-dihydroxyacetochynone on the intrauterine growth retardation of rats produced by passive smoking

作　　者：李郁[1] 熊忠明[1] 司远征[1] 肖慧珠[1] 闪珍珍[1] 吴熙瑞[1] 

机构地区：[1]武汉同济医科大学计划生育研究所

出　　处：《生殖医学杂志》1995年第4期217-220,共4页Journal of Reproductive Medicine

摘　　要：选择１５０只健康ＳＤ妊娠大鼠，均于妊娠Ｄ４～Ｄ２０天仿Ｙｏｕｎｏｓｚａｉ法制备胎儿宫内生长迟缓模型。按治疗药物随机分为６组。观察复方氨基酸和青心酮的疗效。结果：（１）模型组的胎仔平均体重、身长和肝重量都明显低于对照组（Ｐ＜０．０１）。胎仔发育参数各用药组与模型组比较有显著差异（Ｐ＜０．０１）。各用药组之间无明显差异（Ｐ＞０．０５）。（２）孕鼠血红蛋白（Ｈｂ）、红细胞压积（Ｈｔ）水平在模型组明显高于其它５组（Ｐ＜０．０１），各用药组之间无明显差异（Ｐ＞０．０５）。各组胎仔平均体重与母血Ｈｂ、Ｈｔ呈负相关。（３）孕鼠血浆Ｅ３，６－ｋｅｔｏ－ＰＧＦ１ａ水平模型组明显低于其它５组（Ｐ＜０．０１），而ＴＸＢ２无明显改变，ＴＸＢ２／６－ｋｅｔｏ－ｐＧＦ１ａ比值模型组明显高于其它５组（Ｐ＜０．０１）。结果说明青心酮治疗胎儿宫内生长迟缓的药效与其调整ＴＸＡ２－ＰＧＩ２失衡有关。Objectives:To observe the therapeutic effect of 3,4-dihydroxyacetochynone(DHAP)on experimental intrauterine growth retardation(IUGR)in pregnant rats.Design:An experimental animal study.Setting:Reproductive Medicine Center.Tongji Medical University. Methods:A pregnant rat model of IUGR was produced by the rnethod originally described by Younoszai.Plasma levels of E3,6-keto-PG1a and TXB2 were examined by RIA, Hb and Ht of pregnant rats were measured ordinally.Parameters of fetal development including body weight and length,and weight of liver were measured.Results:In groups treated with DHAP at different doses or with compound amino acids, the average body weight and length and weight of liver were significantly higher than those of the control group(P< 0.01).No statistical difference was observed among treated groups. Levels of Hb and Ht of pregnant rats in the control group,which were inversely correlated with body weight of fetus,were remarkbly higher than those of the treated groups(P<0. 001).There was no obvious change in plasma TXB2, but E3 and 6-keto- PGF1a levels of non-treated group were higher than those of treated groups,resulting in a significant higher ratio of plasma TXB2/6-keto-PGF1a in control group.Conclusion:DHAP is effective in treatment of IUGR and its mechanism of action may be due to adjust-ment of PGI2-TXA2 imbalance induced by passive smoking.

关 键 词：吸烟 被动吸烟 胎儿生长迟缓 青心酮 疗效 

分 类 号：R714.431[医药卫生—妇产科学] R163[医药卫生—临床医学]