丙型肝炎患者唾液、精液或阴道分泌物中HCVRNA检测及其传染性研究  

DETECTION OF HCV RNA IN SALIVA,SEMINAL FLUIDS OR VAGINAL DISCHARGE OF PA- TIkNTS WITH HEPATITIS C AND EVALUATION OF THEIR INFECTIVITY

作　　者：黄元成[1] 唐振亚[1] 王苏娜[1] 杨东亮[1] 郝连杰[1] 

机构地区：[1]武汉同济医科大学附属同济医院传染病学教研室临床免疫研究室

出　　处：《肝脏病杂志》1995年第1期24-26,共3页

基　　金：国家八.五科技攻关资助课题

摘　　要：通过对１６例（男７例，女９例）血清ＨＣＶＲＮＡ阳性的输血后丙型肝炎患者唾液、精液、阴道分泌物的ＨＣＶＲＮＡ检测及其配偶和子女的ＨＣＶ感染状况的调查，表明丙型肝炎患者唾液、精液、阴道分泌物中ＨＣＶＲＮＡ均有较高的检出率，以精液最高（５７．１％，４／７），唾液次之（３１．２％，５／１６），阴道分泌物最低（２２．２２％，２／９）。家庭成员中，２例（１２．５０％）配偶感染ＨＣＶ，１６个家庭的子女无一例感染ＨＣＶ。２例引起家庭内传播者均为慢性丙型肝炎患者。结果显示：通过性接触和日常生活接触均有引起丙型肝炎传播的潜在危险性，其中以性接触传播的危险性较大。病程越长，家庭内传播的可能性越大。因此，对ＨＣＶＲＮＡ阳性患者应进行抗病毒治疗，家庭内应进行适当隔离。o investigate the transmission of HCV i nfection through household contact, we detected HCV RNA in saliva,seminal fluids or vaginal discharges of l6 serum HCV RNA positive patients(7 men and 9women) and in sera of their family members,The positive rates of HCV RNA in saliva seminal fluids or vaginal discharges were 31.25%(5/16),57.14%(4/7)and 22. 22%(2/9) respectively. Among the family members in our study all descendants were negative for both anti.HCV and HCV RNA, despite two spouses positive for HCV RNA。 This result strongly suggested the potential possibility of sexual transmission of HCV infection. Therefore, all HCV RNA positive patients should be treated with antivi- ral drugs and isolated in their families.

关 键 词：传染性 HCV RNA 体液 丙型肝炎 

分 类 号：R512.630.1[医药卫生—内科学]