红丝线草醇提水转溶物的降压作用  

The Antihyprtensive Mcchanism of OL-W

作　　者：王宇[1] 杨美玲[1] 

机构地区：[1]暨南大学医学院药理学教研室

出　　处：《暨南大学学报（自然科学与医学版）》1995年第4期22-25,共4页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国务院侨办基金;广东省科委自然科学基金资助项目

摘　　要：２０％的乌拉坦麻醉的大鼠静脉注射ＯＬ－Ｗ（红丝线草醇提水转溶物）分别为ＬＤ５０的１／９０，１／５０、１／３０和１／１０后，平均血压分别下降１５．１％±４．１％、１９．７％±３．８％、２６．８％±７．１％和６７．１％±６．６％，清醒ＳＤ大鼠给予ＯＬ－Ｗ０．８ｇ（生药）７／ｋｇ灌胃后，降压幅度为１．２±０．６ｋＰａ，与给药前相比，Ｐ＜０．０１．在降压机理研究中，ＯＬ－Ｗ脑室给药不引起血压下降，表明ＯＬ－Ｗ的降压部位不在中抠；普萘洛尔、苯海拉明、西米替丁、卡托普利等对其降压作用无明显影响；阿托品可显著减弱其降压作用（Ｐ＜０．０１），提示ＯＬ－Ｗ的降压作用机制可能与Ｍ一受体有关；此外，在整体麻醉开胸猫实验所见，ＴＰｖＲ显著降低，提示其降压机制与直接扩张血管等因素有关。The antihypertensive mechanism of alcoholic extract of water solube HSX(OL-W) werestudied in rats. Four dosage(1/90 of LD50、1/50 of LD50、1/30 of LD50、1/10 of LD50)of HSX(OL-W)were injected via jugular vein,The blood pressure fell downimmediatelly.as follows:(15.1±4.5)%、(19.7±3.8)%、(26.8±7.1)% and(67.1±6.6)%respectilly,The fell was short lived and dose-dependent,the diastolic pressure wasaffed more pronounced. Similar antihypertensive potency but much fonger dunttion(30min)was obeerved after oral adrminaistiation of 0.8g(crud drugs)/kg in the study of mechanism ofhypotensive effect,BP did not change when OL-W was given to cerebral ventricle in rats.Propranolol、dipen-hydraiamine、cintitidine、captoprill did nOt bfock its action,but atrDpine did.These results suggested one that the mechanism of hypotensive action OL-W is concernedwith M-receptor and was related directly with its vosodiating action.

关 键 词：降压作用 M-受体 OL-W 红丝线草水提物 

分 类 号：R972.4[医药卫生—药品]