碱性成纤维细胞生长因子（BFGF）诱变性研究  

STUDY ON THE MUTAGENICITY OF BASIC FIBROBLASTGR0UTH FACTOR(BFGF)

作　　者：马继霞[1] 康三毛 林剑[1] 

机构地区：[1]北京大学生命科学学院,广州暨南大学生物系

出　　处：《癌变．畸变．突变》1995年第6期341-344,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：八五攻关项目

摘　　要：本文应用活体小鼠骨髓细胞染色体畸变（ＣＡ）试验及骨髓嗜多染红细胞（ＰＣＥ）微核（ＭＮ）试验，对碱性成纤维细胞生长因子（ＢＦＧＦ）的诱变活性进行为期ｌＷＫ、２ＷＫ及４ＷＫ的实验研究。结果表明：经ＢＦＧＦ处理的实验各组微核率与正常对照组比较无显著性差异（Ｐ＞０．０５），但是，染色体畸变试验结果揭示，其与对照组比较显示出一定的诱变活性。ＣＡ及ＭＮ两种方法测定结果均无剂量效应关系。The micronucleus in polychromatic erythrocytes(PCE)of mouse bone -marrowand chromosomal aberration were counted for studying the mutagenicity of basic fibroblast growth factor(BFGF).Results showed that there was no difference among testing groups themselves and the vehicle control (P>0. 05 ).In other hand,there was differences in the chromosome aberration in comparing with the negative control . However,no differences was found among groups with various treatments 。

关 键 词：碱性纤维细胞 生长因子 BFCF 卫生毒理 化妆品 

分 类 号：R114[医药卫生—卫生毒理学]