抗早孕新药抗孕唑对大鼠的胚胎毒性和致畸作用研究  

EMBRYOTOXICITY AND TERATOGENICITY OF CONTRAGES-TAXZOL,ANEW EARLY PREGNANCY TERMINATING AGENT,IN RAT

作　　者：应赢[1] 方瑞英[1] 

机构地区：[1]浙江杭州医科大学药学系药理学教研室

出　　处：《癌变．畸变．突变》1995年第6期355-358,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：测试了抗孕唑的胚胎毒性和致畸性。大鼠于孕ｄ６－ｄｌ５分别肌注抗孕唑０．０１，０．１与０．２ｍｇ／ｋｇ／ｄ。结果，抗孕唑中、高剂量组大鼠妊娠后期体重明显较低。三剂量组吸收胎数分别为２．１土２．４，６．７土３．６和１１．０１２．４，显著较高。受试组胎鼠体重、身长和尾长则无显著差异。胎鼠外观、内脏和骨骼检查均无明显畸形。但中、高剂量组胎鼠颅骨骨化不全率（１４．７％，２０．０％）显著高于溶剂组（１．１％）。因此，除使胎鼠发育轻度迟缓和颅骨骨化不全外，抗孕唑无明显致畸胎作用。The teratogenicity of contragestazol(DL111-IT)was tested.Sprague-Dawley rats were treated with im 0.01,0.l and 0.2mg/kg of contragestazol from day 6 to day l5 of gestation。The rats were necropsied on day 20 and their fetuses were examined with routine protocol.The body weight of the rats received contragestazol was decreased in late pregnan-cy. The resorptions were 2.1士2.4,6.7±3.6 and ll.0±2.4 respectively among the test groups(P<0. 0l).The body weight and the length of tail and body were not significantly dif-fered.No marked malformation was found in all test groups。 But the freqencies of retardation of ossifications of skull in 0.land 0.2mg/kg of contragestazol were l4.7%and 20.0%,re-spectively(P<0.01).In conclusion ,contragestazol posseses little embryotoxicity except re-tarded ossification of skull and slightly delayedness of development at dosage,below terminat-ing early pregnancy。

关 键 词：抗孕唑 抗早孕药 引产药 致畸性 胚胎毒性 

分 类 号：R979.22[医药卫生—药品]