金丝桃甙对中枢神经系统的一般药理作用  

The inhibitory effects of hyperin on central nervous system

作　　者：宋必卫[1] 陈志武[1] 马传庚[1] 岑德意[1] 张于江[1] 方明[1] 江琴[1] 徐叔云[1] 

机构地区：[1]安徽医科大学药理教研室

出　　处：《安徽医科大学学报》1995年第4期253-255,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省卫生厅资助

摘　　要：本文研究金丝桃甙（Ｈｙｐｅｒｉｎ，Ｈｙｐ）对中枢神经系统的一般药理作用。实验发现：①ｉｐＨｙｐ１２．５～５０ｍｇ·ｋｇ^（－１）呈剂量依赖性减少小鼠活动；②ｉｐＨｙｐ１２．５～５０ｍｇ·ｋｇ^（－１）轻度减少家兔的肺通气量但无明显量一效关系，且呼吸频率不受影响，ｉｖＣａＣｌ＿２可拮抗Ｈｙｐ减少肺通气量的作用；③ｉｐＨｙｐ１００ｍｇ·ｋｇ^（－１）不能拮抗士的宁所致的小鼠惊厥发作和死亡。上述结果表明：Ｈｙｐ具有镇静作用，虽减少肺通气但不抑制呼吸中枢节律活动。The general effects of hyperin on central nervous system were studied. The resultsshowed that hyperin could produce the dose-dependent sedation (12. 5～50 mg·kg￣(-1), ip)but neither the hyponosis (150 mg· kg￣(-1), ip) nor the anticonvulsion tested on the strychinine-induced convulsion model (100mg. kg￣(-1), ip) in mice. It was also found that hyperin at doses of 12. 5～50 mg. kg￣(-1) (ip) could slightly decrease the respiratory volumes in a nondose-dependent manner with a ceiling rate of inhibition of 37.9% but not influence the frequencies of respiration in rabbits, and iv CaCl_2, could antagonize the negative effect of hyperin on the respiratory volume. So it is concluded that hyperin might be a depressant of central nervous system which differs from barbiturates, benzodiazepines and opioids.

关 键 词：镇静剂 金丝桃甙 中枢神经系统 抑制药 

分 类 号：R971.3[医药卫生—药品]