维生素E对冷暴露大鼠脂质过氧化作用的影响  

EFFECT OF VITAMIN E ON LIPID PEROXIDATION OF RATAFTER COLD EXPOSURE

作　　者：宋志宏[1] 任明[1] 高应[1] 蒋秉坤[1] 

机构地区：[1]中山医科大学第一附属医院,山西医学院

出　　处：《蚌埠医学院学报》1995年第2期78-80,共3页Journal of Bengbu Medical College

摘　　要：大鼠于低温暴露后血及肝脏组织中ＬＰＯ含量显著升高，而ＧＳＨ－Ｐｘ和ＳＯＤ活性明显下降。冷暴露动物饲料中加入一定量的ＶＥ可明显改善上述指标的变化，接近于室温下正常对照组水平，表明ｖＥ可通过其抗脂质过氧化作用，提高机体的耐寒力。Changes of lipid peroxides(LPO)content,activities of glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)in blood and liver of rats with vitamin E incorporated intothe feed were determined after cold exposure to observe their effects。 LPO content markedly in- creased,but the activities of GSH-Px and SOD decreased significantly,Vitamin E could make theabove values close to levels of the control group。 Vitamin E might enhance rat tolerance to coldthrough anti-lipid peroxidation。

关 键 词：维生素E 冷暴露 脂质过氧化物 药理学 

分 类 号：R977.25[医药卫生—药品]