白细胞介素－1对大鼠离体孵育胃粘膜细胞损伤的保护作用  

PROTECTIVE EFFECT OF INTERLEUKIN-1 ON GASTRIC MUCOSAL CELL DAMAGE IN VITRO

作　　者：黄忠[1] 李铁[1] 于吉人[1] 

机构地区：[1]北京医科大学生理学系

出　　处：《北京医科大学学报》1995年第4期259-260,266,共3页Journal of Peking University(Health Sciences)

基　　金：国家自然科学基金

摘　　要：观察了不同剂量的白细胞介素－１（ＩＬ－１）对乙醇诱导的离体孵育胃粘膜细胞损伤的影响。用５％的乙醇造成胃粘膜细胞损伤，观察到ＩＬ－１对乙醇引起的胃粘膜细胞损伤具有直接的保护作用，表现在细胞存活率升高及细胞内乳酸脱氢酶（ＬＤＨ）漏出减少。提示ＩＬ－１对胃粘膜细胞具有直接的保护作用，这也可能是其整体保护作用的机制之一。e observed the effect of interleukin-1(IL-1)on damage of gastric mucosal cells induced by ethanol in vitro.Protreatment of IL-1 could markedly reduce the damage of mucosal cells induced by 5%ethanol.It was foundthat the survival ratio of mucosal cells was increased and the intracellular LDH leakage was decreased.These sug-gest that IL-1 could directly protect the gastric mucosal cells and this effect might explain the protective mecha-nism of IL-1.in vivo.

关 键 词：白细胞介素-1 药理学 胃粘膜损伤 大鼠 

分 类 号：R978.5[医药卫生—药品] R965.1[医药卫生—药学]