SOD及4种Cu（Ⅱ）络合物脂质体的SOD样活性  

SOD-LIKE ACTIVITY OF SOD AND CU(Ⅱ)COMPLEX IN LIPOSOMES

作　　者：刘艳[1] 孙静[1] 李连涛 鲁纯素[1] 

机构地区：[1]北京医科大学药学院物化教研室

出　　处：《北京医科大学学报》1995年第4期319-320,共2页Journal of Peking University(Health Sciences)

基　　金：国家自然科学基金

摘　　要：选择了ＳＯＤ及４种Ｃｕ（Ⅱ）络合物，以Ｃｙｔ．ｃ－ＨＸ－ＸＯ法，测其ＳＯＤ样活性；同时，采用反相蒸发法制备了ＳＯＤ及其模拟物的大单层脂质体，以相同的方法测定其ＳＯＤ样活性。结果表明，所有体系均有某种程度的活性，其中Ｃｕ（Ｈｉｓ）２－脂质体体系活性最高，且药物在脂质体中的活性均比在缓冲体系中有不同程度的提高。SOD-like activities of SOD and four Cu(Ⅱ)complexes {Cu(Hsal)2,Cu(His)2,Cu(Dopa)2,Cu(Rutin)2}inphosphate buffer(pH=7.4)and in liposomes were determined,using cytochrome-c method.The results showedthat all of the systems had SOD-like activity to some extent and the Cu(Ⅱ)complex-liposomes systems had an ap-parent positive cooperative action in which the Cu (His)2-liposome system displayed the highest activity. These re-sults could be explained by micellar catalysis and chemical action.

关 键 词：超氧化物歧化酶 铜铬合物 脂质体 代谢 

分 类 号：R977.3[医药卫生—药品] Q554[医药卫生—药学]