氯苯扎利二钠的抗炎作用  

ANTI-INFLAMMATORY EFFECT OF LOBENZARIT DISODIUM

作　　者：李卫东[1] 王格林[1] 马俊江[1] 林志彬[1] 

机构地区：[1]北京医科大学药理学系

出　　处：《北京医科大学学报》1995年第4期297-299,共3页Journal of Peking University(Health Sciences)

摘　　要：报道氯苯扎利二钠（ＣＣＡ）对几种动物炎症模型的影响。结果表明，大剂量ＣＣＡ（１００ｍｇ／ｋｇ，ｉ．ｐ．）对角叉菜胶所致大鼠足肿胀及二甲苯诱发的小鼠耳部肿胀两种急性炎症模型有明显抑制作用；ＣＣＡ连续用药６天可明显抑制大鼠琼脂肉芽肿，对炎症的晚期反应亦有影响；ＣＣＡ对ＡＡ大鼠的急性炎症相及继发性炎症相均有抑制作用，以１０ｍｇ／ｋｇ剂量组效果最好。he anti-inflammatory effects of Lobenzarit Disodium(CCA)were studied in rats and mice.CCA ig(25,50,100 mg/Kg)inhibited the swelling of mouse pinnea induced by xylene,it could also suppress the edema of rat’s hind paws elicited by injection of 1%carrageenin,and the granuloma induced by agar-agar in mice could be inhibit-ed.CCA also showed a significant inhibition on the adjuvant arthritis induced by Freund’s adjuvant in rats.Thisaction was non-dose-dependent.The results indicate that CCA has definitely anti-inflammatory effects.

关 键 词：免疫调节剂 氯苯扎利二钠 抗炎作用 

分 类 号：R979.5[医药卫生—药品]