药物载体──马来酸酯化淀粉共聚物微球的合成研究  

SYNTHESIS OF DRUG CARRIER-COPOLYMER MICROSPHERE OF STARCH MALEIC ACID ESTER

作　　者：李连涛[1] 侯新朴[1] 沈惠明 

机构地区：[1]北京医科大学药学院物化教研室

出　　处：《北京医科大学学报》1995年第5期393-395,共3页Journal of Peking University(Health Sciences)

摘　　要：以马来酸酐和淀粉为原料合成了马来酸酯化淀粉，在逆相乳液聚合体系中合成了马来酸酯化淀粉－丙烯酸共聚物微球，微球粒径主要在２０～４０μｍ，探讨了酯化度、表面活性剂、水相浓度以及转速等对微球制备的影响。tarch microsphere can easily be prepared by copolymerization of maleic starch ester with acrylic acid in a wa-ter-in-oil emulsion. The microsphere,preferably around 20～40μm in diameter,will have a microporous structureformed by the network. Effects of preparative condition on the microsphere are investigated.

关 键 词：缓释制剂 药物载体 马来酸酐 淀粉微球 

分 类 号：R944.9[医药卫生—药剂学]