高血压对糖尿病微血管病变患者血浆TXB2浓度的影响  

EFFECT OF HYPERTENSION ON PLASMA THROMBOXANE B2 IN PATIENTS WITH DIABETIC MICROANGIOPATHY

作　　者：胡肇衡[1] 赵伟河[1] 毛腾淑[1] 李立新[1] 

机构地区：[1]北京医科大学人民医院内分泌科,北京医科大学人民医院眼科,河南省荣康医院。

出　　处：《北京医科大学学报》1995年第5期367-369,共3页Journal of Peking University(Health Sciences)

摘　　要：用放射免疫法测定２０４例糖尿病人的血浆ＴＸＢ２和６－Ｋｅｔｏ－ＰＧＦ１ａ浓度。各组的ＴＸＢ２水平，随糖尿病视网膜病变或糖尿病肾病加重而升高。各糖尿病微血管病变组中高血压组ＴＸＢ２水平均高于血压正常组（Ｐ＜０．０５）。提示ＴＸＢ２在糖尿病微血栓形成中起重要作用，合并高血压时对糖尿病微血管病变的发生和进展有明显的促进作用。e measured plasma thromboxane B2 and 6-keto-prostaglandin F1ausing radioimmunoassay in 204 diabetic pa-tients. The results showed that the TXB2 level was significantly higher in diabetic retinopathy or diabetic nephropathy groups than that in normal subjects(P<0. 01 ).The TXB2 level in hypertensive diabetic patients from each of the above groups was significantly higher than those of normotensive patients in the same group(P< 0.05).Our results suggest that thromboxane B2 may involve in the pathogenesis of microangiopathy in diabetesmellitus and hypertension may play a role in the progression of diabetic microangiopathy.

关 键 词：糖尿病 微血管病变 并发症 高血压 血栓素 

分 类 号：R587.202[医药卫生—内分泌]