新生儿超氧化物歧化酶及其临床意义  

A study on the activity of blood superoxide dismutase and its clinical significance in newborn infants

作　　者：侯金珍[1] 范睦蕾 郭素琼[1] 马兰[1] 郭昌燕[1] 蒋鸿鑫[1] 祖秀松[1] 马俊荣[1] 

机构地区：[1]首都医科大学附属北京友谊医院儿科,首都医科大学附属北京友谊医院中心实验室,首都医科大学附属北京友谊医院产科

出　　处：《北京医学》1995年第2期75-77,共3页Beijing Medical Journal

摘　　要：本文采用微量血免疫扩散法检测１７１例新生儿脐血超氧化物歧化酶（ＳＯＤ）．其中正常新生儿１１１例、胎儿异常（脐带绕颈、胎儿宫内窘迫）３０例、孕母异常（胎膜早破、妊娠中毒症）１６例及新生儿窒息１４例。结果提示：新生儿窒息组及孕母异常组的脐血ＳＯＤ含量显著降低（Ｐ＜０．０５），而其它组未见明显变化。本文材料提示ＳＯＤ测定可间接评价氧自由基体内平衡情况，ＳＯＤ活性下降提示体内氧自由基增加。Superoxide dismutase (SOD) activity was measured with immunodiffusion technique (micromethod) in the umbilical cord blood samples of 171 newborn infants. of which 111 infants were clinically normal(group 1), 30 infants were abnorma 1 (group 2,including cord rounding the fetal neck and fetal distress).16 infants were born to mothers of complicated pregnancies (group 3, including premature rupture of the mambranes and toxemia) and 14 infants were those with asphyxia (group 4). A significant decline in SOD activity, was observed in group 3 and 4(P<0.05), while there was no significant change in enzyme acitivity in the remaining two groups. The present data indicate that SOD activity determination maybe used to evaluate free radical homestasis indirectly, and that reduced enzyme activity suggests in vivo oxygen free radical accumulation.

关 键 词：新生儿窒息 超氧化物歧化酶 脐血 

分 类 号：R446.112[医药卫生—诊断学] R722.12[医药卫生—临床医学]