比索洛尔和安替洛尔治疗原发性高血压的随机双盲研究  

Randomized double blind study of bisoprolol versus atenolol in treatment of essentinal hypertension

作　　者：陈端霞[1] 游凯[1] 朱文玲[1] 严晓伟[1] 张抒扬[1] 商怀君 戴玉华[1] 

机构地区：[1]中国医学科学院北京协和医院

出　　处：《北京医学》1995年第4期198-200,共3页Beijing Medical Journal

摘　　要：５９例原发性高血压患者随机双盲分为比索洛尔（ｂｉｓｏｐｒｏｌｏｌ，简称Ｂｓｐ）组及安替洛尔（ａｔｅｎｏｌｏｌ，简称Ａｔｅ）组，比较两组降压疗效，Ｂｓｐ组总有效率为１００％，Ａｔｅ组总有效率为９６．４％。两组疗效无显著性差异。两组均有减慢心率作用，对血糖、血脂、肝肾功能、血清电解质、尿酸、血尿常规均无明显不良反应。两种药物作用时间较长，可每日服药１次。In a randomized double blind placebo controlled study, 59 cases with WHO Grades Ⅰ～Ⅱessential hypertension were treated with bisoprolol(Bsp)or atenolol(Ate ) for 4 weeks.The results showed that total effective rate were 100%and 96.4%for Bsp and Ate respectively.No severe adverse side effects were found in the course of therapy with Bsp and Ate. Bisoprolol may be used as a safe and effective antihypertensive drug in the treatment of WHO Grades Ⅰ～Ⅱessential hypertension.

关 键 词：原发性 高血压 比索洛尔 安替洛尔 药物疗法 

分 类 号：R544.105[医药卫生—心血管疾病] R972.4[医药卫生—内科学]