消痞灵冲剂对大鼠胃癌前病变DNA含量和细胞动力学影响的定量研究  

Quantitative Research of the Influence of Xiaopiling Granule on DNA Content and Cyto-Dynamics of Rat Gastric Precancerosis

作　　者：张旭晨[1] 赵凤志[1] 代欣 田德录[1] 董建华[1] 

机构地区：[1]北京中医药大学附属东直门医院,承德医学院病理教研室

出　　处：《北京中医药大学学报》1995年第1期41-49,共9页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家"八五"攻关课题

摘　　要：采用大鼠胃癌前病变模型，运用流式细胞仪测定了中药消痞灵冲剂对胃癌前病变ＤＮＡ含量和细胞动力学的影响。结果显示，中药消痞灵冲剂预防和治疗组的ＤＮＡ指数、Ｓ期和Ｇ２／Ｍ期细胞数、细胞增殖指数，与正常组相比无显著性差异（Ｐ＞０．０５），而与病变组相比有显著性差异（Ｐ＜０．０５）。结果表明，中药消痞灵冲剂对大鼠胃癌前病变有明显的抑制作用。Applying model of rat gastric precancerosis and flow cytometry to assay the influence of Xiaopiling Granule on DNA content and cyto-dynamics of gastric precancerosis. Results:In both prevention and treatment groups of Xiaopiling Granule, the DNA index, cell number and cell proliferation index at S and G2/M stages had no obvious difference from those in normal group (p>0.05), but had obvious difference from those in pathological group (p<0.05). The results shown that Xiaopiling Granule had a distinctive inhibition effect on rat gastric precancerosis.

关 键 词：消痞灵冲剂 胃肿瘤 流式细胞仪 癌 DNA 

分 类 号：R273.520.5[医药卫生—中西医结合] R285.5[医药卫生—中医肿瘤科]