消痞灵冲剂对实验性胃癌前期病变大鼠胃粘膜胃螺旋样菌感染的防治作用  

Study of the Preventive and Curative Effect of Xiaopiling Granule on GHLO Infection of Gastric Precancerous Lesion in Rats

作　　者：张旭晨[1] 赵凤志[1] 代欣[1] 鲁香凤[1] 古雪迎 方杰[1] 

机构地区：[1]北京中医药大学附属东直门医院

出　　处：《北京中医药大学学报》1995年第4期59-62,共4页Journal of Beijing University of Traditional Chinese Medicine

摘　　要：采用综合法复制了大鼠胃癌前期病变模型，并观察了大鼠胃粘膜胃螺旋样菌的感染情况及中药消痞灵冲剂对其防治作用的影响。结果显示：模型组和自然恢复组大鼠胃螺旋样菌感染数量明显高于正常对照组，大、中、小３个剂量的消痞灵冲剂对其感染有明显的抑制作用。表明：胃螺旋样菌感染参与了大鼠胃癌前期病变的发生和发展，对胃螺旋样菌的抑制作用可能是消痞灵冲剂发挥防治作用的机制之一。Model of gastric precancerous lesion was prepared by using synthetical method and its gastric helicobacter-like organism (GHLO)infetion and the prevenive and curative effect of Xiaopiling Granule (XPL)on it were observed. The results showed that the number of CHLO in model group and spontaneous recovery group were Increased significantly than that in the normal group. The administration of large or moderate or small dose of XPL could inhibit the CHLO infection distinctively, but the positive contrast medicine Weimeisu had no effect on it. The results indicated that the CHLO infection played some roles in the genesis and progress of gastric precancerous lesion and the inhibition effect on GHLO infection might be one of the mechanisms of XPL's preventive and curative effect on gastric precancerous lesion.

关 键 词：胃肿瘤 胃癌前病变 幽门螺杆菌 消痞灵冲剂 防治 

分 类 号：R273.52[医药卫生—中西医结合] R286.91[医药卫生—中医肿瘤科]