去氢紫堇碱对兔血小板TXB_2及主动脉6-keto-PGF1PGF_1α含量的影响  

EFFECT OF DEHYDROCORYDALINE ON FORMATION OF THROMBOXANE B_2 IN PLATELETS AND 6-KETOPGF_(1α) IN RABBII AORTA

作　　者：杨军[1] 王义明[1] 柴瑞华[1] 

机构地区：[1]辽宁中医学院药理教研室,沈阳110032

出　　处：《药学学报》1989年第6期471-475,共5页Acta Pharmaceutica Sinica

摘　　要：去氢柴堇碱（dehydrocorydaline,DHC）是从罂栗科植物延胡索块茎中提取的一种季胺类生物碱（其结构式如下）。实验证实延胡索治疗冠心病的有效成分为DHC。DHC对心血管系统的药理研究也有报道。近年的实验证明DHC有升高血小板内cAMP含量的作用并抑制ADP诱导的血小板第四因子（PF4）的释放。Dehydrocorydaline (DHC) was shown to reduce the production of thromboxane B_2 (TXB_2)in platelets and 6-keto-prostaglandin F_(1α) (6-keto-PGF_(1α) in the aorta of rabbits in vitro. The effect of DHC increased with the increase of dose.DHC 0.41 mg was found to inhibit the formatiom of TXB_2 markedly while not reduce the content of 6-keto-FCF_(1α). DHC also exhibited obvious inhibitory effect on the arachidonic acid (0.66mmol/L) induced formation of platelet malondialdehyde (MDA). These effects were similiar to the specific cycloxygenase inhibitor, aspirin (0.03 mg/ml). The results suggest that (1) DHC reduced both contents of TXA_2 and PGI_2 in vitro. (2) DHC markedly inhibited the system of cycloxygenase in cell microsomes. (3) As to whether TXA_2 synthetase or cycloxygenase was inhibited in these experiments is still to be elucidated.

关 键 词：去氢紫堇碱 血栓素B2 前列腺素F1Α 

分 类 号：R965.4[医药卫生—药理学]