毛梗稀莶抗生育活性成分的研究  

STUDIES ON ANTIFERTILITY CONSTITUENTS OF SIEGESBECKIA GLABRESCENS MAK

作　　者：董祥英[1] 陈敏[1] 荆伟 黄大宪 沈珊梅 李惠庭[1] 

机构地区：[1]国家医药管理局上海医药工业研究院,上海200040

出　　处：《药学学报》1989年第11期833-836,共4页Acta Pharmaceutica Sinica

摘　　要：自菊科植物毛梗豨莶Siegesbeckia glabrescens Mak的全草中分得一个新的二萜甙,命名为豨莶新甙(neodarutoside),经光谱(IR,~1 HNMR,^(13) CNMR和MS)分析,确定结构为(I);同时分得的二萜有豨莶精醇(darutigenol,Ⅳ)和豨莶甙(d&rutoside,Ⅴ)。豨莶甙(Ⅴ)在20～40 mg/kg剂量时,对大鼠有明显抗早孕作用。Three diterpenes including a new compoud were isolated from the whole plant of Siegesbeckia glabrescens Mak. The new one was named as neodarutoside and its structure was elucidated as ent-3α,15,16-trihydroxy pimarane 3,15-his- (β-glucopyranoside) based on the spectral evidence and chemical transformation.The other two were darutigenol and darutoside. Darutoside possesses the activity of termination of early pregnancy in experimental rats at a dosage of 20～40 mg/kg.

关 键 词：毛梗xi莶 抗生育剂 活性成分 

分 类 号：R284.2[医药卫生—中药学]