自发性高血压大鼠不同脑区5－HT_（1A）受体的结合特征  

5-HT_(1A) receptor binding in the central nervous system of spontaneously hypertensive rats

作　　者：周静[1] 刘垣升[1] 唐仲进[1] 陈红[1] 苏定冯[1] 张黎明[1] 陆赛花 

机构地区：[1]第二军医大学基础医学部药理学教研室,第二军医大学教学保障处

出　　处：《第二军医大学学报》1995年第4期318-321,共4页Academic Journal of Second Military Medical University

摘　　要：用放射性配基［＾３Ｈ］８－ＯＨ－ＤＰＡＴ结合实验显示，自发性高血压大鼠（ＳＨＲ）脑区的海马、延髓、下丘脑５－ＨＴ１Ａ受体的结合位点明显高于正常Ｗｉｓｔａｒ Ｋｙｏｔｏ（ＷＫＹ）大鼠，其中海马增加最多。在此基础上用抗高血压药普萘洛尔给ＳＨＲ灌胃，结果脑区不同部位受体结合参数、血压及心率都有不同程度的变化，更接近于ＷＫＹ大鼠。Scatchard analysis showed that the maximal number of [￣3H]8-OH-DPAT binding site(B_(max)) was significantly increased in the preparation of the hippocampus,medulla oblongata and hypothalamus of spontaneously hypertensive rats(SHR) when compared to normotensive Wistar Kyoto(WKY) rats. The amount of B_(max) in the hippocampus was the highest. Propranolol (10 mg·kg￣(-1)·d￣(-1)p.o. for 20 d)significantly reduced the number of 5-HT_(1A) receptor in various membrane preparations and blood pressure of SHR,while,changed the heart rate of SHR. These results suggest that the difference between SHR and normotensive rats in the 5-HT_(1A) receptor in various brain regions may be related to the generation of the hypertension.

关 键 词：受体 普萘洛尔 羟色胺 高血压 

分 类 号：R544.102[医药卫生—心血管疾病] R975.4[医药卫生—内科学]