改良豚鼠至大鼠异种异位心脏移植模型  

An improved model of heterotopic cardiac xenotransplantation from guinea pigs to rats

作　　者：邹良建[1] 张宝仁[1] 朱家麟[1] 郝家骅[1] 蔡凯华[1] 

机构地区：[1]上海第二军医大学长海医院胸心外科

出　　处：《第二军医大学学报》1995年第5期446-448,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金

摘　　要：在Ｃｕｆｆ技术的基础上进行改良，通过１１２例移植实验，成功地建立了豚鼠至大鼠异种颈部心脏移植模型，仅２例失败，手术成功率为９８．２％，豚鼠移植心平均存活时间１４．５±５．５ｍｉｎ。结果提示：改良豚鼠至大鼠异种颈部心脏移植术操作简便，出血少，手术成功的可重复性高，是研究非协调性异种心脏移植超急性血管排斥机制及抗排斥方面既实用又稳定可靠的实验动物模型。The shortage of allogenic donor heart is still a serious problem all over the world,which leads to a heat in the study of xenografic cardiac transplantation.This study,based on Cuff technique,modified the grafting procedure in some aspects and successfully established a model of cervical cardiac xenotransplantation from guinea pigs to rats.A total of 112 xenografting procedures were performed in this group,and the success rate was 98.2%,with only 2 cases of operative failure. Mean survival of the xenograft was 14.5±5.5 min.The result shows that the improved model is easily available and highly reproducible with less bleeding.It provides a practical and stable experimental means for studying the mechanisms of hyperacute vascular rejection and the prevention of rejection in discordant cardiac xenotransplantation.

关 键 词：异体 心脏移植 动物模型 

分 类 号：R654.205[医药卫生—外科学]