阿西莫司、普鲁布可、川芎嗪对兔主动脉粥样硬化的影响  

Effects of acipimox,probucol and ligustrazine on atherosclerosis in rabbits

作　　者：王志华[1] 张国元[1] 王华梁[1] 

机构地区：[1]第二军医大学长征医院心内科,山东兖州解放军第91医院心内科

出　　处：《第二军医大学学报》1995年第5期417-419,共3页Academic Journal of Second Military Medical University

摘　　要：用雄性新西兰兔制作动脉粥样硬化（ＡＳ）模型，随机分为普通饲料组、高脂饲料组、阿西莫司组、普鲁布可及川芎嗪组，每组７只。实验１６周后研究各组兔主动脉病变范围并验血脂及血浆内皮素（ＥＴ）含量。结果显示：普鲁布可组及川芎嗪组血脂明显降低；高脂饲料组ＥＴ－１明显高于普通饲料组及３个药物组；普通饲料组兔主动脉内膜无病变，高脂饲料组病变面积占８１．４４％，阿西莫司组、普鲁布可组及川芎嗪组则分别为６８．９７％、６２．３３％及３０．４１％，均明显少于高脂饲料组，相差显著。提示这３种药物明显干预ＡＳ形成，在临床防治ＡＳ方面有较好的应用前景。The model of experimental atherosclerosis(AS) was established in rabbits by means of hyperlipid-fed and hyperlipid-fedcombined with acipimox or probucol or ligustrazine.When AS occurred,the content of serum total cholesterol(TC) and triglycerides(TG) and plasma endothelin-1(ET-1) increased,but that in probucol TC and TG decreased when ligustrazine TC decreased.The changes had significant difference as compared with the hyperlipid-fed control(P<0.0 1),The aortic atherosclerotic plaque in acipimox,probucol and ligustrazine had significant derease as compared with the hyperlipid-fed control(P<O.05,0.0.1,0.01).These results show that the three drugs can all reduce the AS occurrence and degree of the lesion and reduce plasma lipid and ET-1.They have clinical value for prevention and treatment of AS.

关 键 词：阿西莫司 普鲁布可 川芎嗪 动脉粥样硬化 血脂 

分 类 号：R543.505[医药卫生—心血管疾病]