妊娠期肝内胆汁淤积症与血清甘胆酸的关系  

Clinical value of measuring serum cholylylycine in patients with intrahepatic cholestasis of pregnancy

作　　者：左万兴[1] 张令浩[1] 

机构地区：[1]第二军医大学长征医院妇产科,上海市宝山区吴淞中心医院妇产科

出　　处：《第二军医大学学报》1995年第5期473-475,共3页Academic Journal of Second Military Medical University

摘　　要：检测了７４例正常足月妊娠妇女和５６例妊娠期肝内胆汁淤积症（ＩＣＰ）患者血清甘胆酸（ＣＧ）的浓度。结果ＩＣＰ患者血ＣＧ浓度显著升高（１３．５２±９．５４ｍｇ／Ｌ），为正常孕妇（２．６７±１．９２ｍｇ／Ｌ）的５～１０倍。根据血ＣＧ浓度将ＩＣＰ患者分为＜１０、１０～２０、＞２０ｍｇ／Ｌ３组，将３组胎儿出生情况与正常组相对照，结果显示血ＣＧ浓度＜１０ｍｇ／Ｌ组羊水胎粪污染率及新生儿窒息率与正常组无差异，而血ＣＧ浓度中、重度升高组羊水胎粪污染率及新生儿窒息发生率显著高于正常孕妇组（Ｐ＜０．０１）。提示：测定血ＣＧ浓度对诊断ＩＣＰ、判断病情及胎儿结局具有重要意义。Markedly elevated serum cholylglycine(CG) concentration is a characteristic index for patients with intrahepatic cholestasis of pregnancy(ICP).This study showed that the concentration of serum CG in 56 patients with ICP was markedly elevated to 13.52±9.54 mg/L ,which was 5～10 times more than that of 74 normal term pregnancies(2.67±1.92 mg/L).Patients with ICP were divided into three sub-groups according to their concentrations of serum CG(<10、10～20 and >20 mg/L).As compared with 74 pregnancies of normal serum CG concentrations,there were no statistically significant differences between serum CG concentration <10 mg/L group and normal pregnancy regarding to the rates of meconium-stained aminiotic fluid and neonatal asphyxia,but the rates of meconium-stained amniotic fluid and neona tal asphyxia were significantly higher in moderate-severe elevated serum CG concentration groups(P<0.01).This indicates that the measurement of serum CG concentration is very important for diagnosing ICP,evaluating disease and predicting the fetal outcome.

关 键 词：胆汁淤积 妊娠并发症 甘胆酸 

分 类 号：R714.255[医药卫生—妇产科学]