氧惊厥大鼠一些脑区内生长抑素含量的变化  被引量:2

Changes of somatostatin content in some brain areas of rats during oxygen-induced convulsion

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作  者:胡长虹[1] 倪国坛[1] 杭荣椿[1] 

机构地区:[1]第二军医大学海军医学系潜水医学教研窒

出  处:《第二军医大学学报》1995年第6期524-524,共1页Academic Journal of Second Military Medical University

摘  要:用放射免疫分析技术测定大鼠在600kPa高压氧暴露下海马、纹状体和额叶皮质中生长抑素(SS)含量的变化,并在700kPa高压氧暴露下,观察腹腔内注射半胱胺(CSH)及侧脑室内注射SS抗血清对大鼠氧惊厥始发时间(Initialtimeofconvulsion;ITC)、惊厥严重程度(Severityofconvulsion;SOC)和氧惊厥大鼠存活时间(Survivaltime;ST)的影响。结果显示大鼠濒临氧惊厥时海马、纹状体中SS含量显著升高,氧惊厥时所观察脑区SS含量均显著升高;CSH和SS抗血清预处理显著延迟大鼠ITC,减轻SOC和延长其ST。提示SS可能参与氧惊厥发作过程,并可能是导致氧惊厥的内源性物质之一。The content of somatostatin (SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay.Initial time of convulsion, severity of convulsion and survival time of rats with convulsion exposed to 700 kpa hyperbaric oxygen after intraperitoneal injection of cysteamine or intracerebroventricular injection of anti-somatostatin serum were also observed.The results showed that the content of SS in hippocampus and striatum tissues increased markedly before rats were at unconvulsion, by the time rats developed convulsion,it had a significant increase in all of the brain areas observed. Intraperitoneal injection of cysteamine or intracerebroventricular injection of anti-somatostatin serum could delay initial time of convulsion,prolong survival time and decrease severity of convulsion.These results suggest that SS might play a role in oxygen-induced convulsion and be one of the endogenous agents which caused oxygen-induced convulsion.

关 键 词:生长抑素 氧惊厥 海马 纹状体 高压氧 氧中毒 

分 类 号:R595.9[医药卫生—内科学] R595.1[医药卫生—临床医学]

 

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