硫氮酮防治实验性动脉粥样硬化的研究  

Prevention of Experimental Atherosclerosis with Diltazem

作　　者：吴明媚[1] 张宁仔 王存兰 李洁焕[1] 史俊忠[1] 谢伯雅[1] 邓明亮[2] 

机构地区：[1]唐都医院心血管内科 [2]唐都医院检验科

出　　处：《第四军医大学学报》1989年第3期173-176,共4页Journal of the Fourth Military Medical University

摘　　要：给家兔喂饲胆固醇和疏氮(艹卓)酮,观察其血清和主动脉壁脂质及钙的含量,血液流变学变化和主动脉壁粥样硬化病变的程度。结果,硫氮(艹卓)酮组胆固醇和甘油三酯增加较对照组少(P<0.01),主动脉壁钙含量较对照组低,主动脉壁粥样硬化病变程度较对照组轻(P<0.01)。电镜下观察硫氮(艹卓)酮组的心肌超微结构,见心肌内毛细血管显著扩张,心肌细胞多较完整,无核周水肿,细胞受损较轻。对照组则相反,以上结果表明硫氮(艹卓)酮可能有降低血脂,阻止主动脉壁钙沉着,减轻或延缓主动脉粥样病变发生和对喂饲高胆固醇家兔的心肌起保护作用。Feed rabbits with cholesterol and diltiazem and measure the lipide and calcium content in serum and on the aortic wall, and observe the hemorrhelogic variation and the atherosclerotic lesion extent of the aortic wall. As a result, cholesterol and triglyceride increased less in the diltiazem group(DG) than in the control group (CG) (P<0.01); the calcium content of the aortic wall in DG is lower than that in CG; and the occurrance of atherosclerotic lesion on the aortic wall in DG's case is less serious than that in CG (P<0.01). Through electron microscopic observation of the myocardium ultramicrostructure of the DG, it was found that most myocardial capillaries were dilated and most myocardial cells in right condition without edema around the mucleus; and the cells are less impaired. The situation with the CG is just the opposite. The experimental results indicate that diltiazem can reduce lipoidemia, resist calcinosis on the aortic wall, alleviate or retard the formation of aortic atherosclerotic lesion, and protect the myocardium of high-cholesterol-fed rabbits.

关 键 词：动脉粥样硬化 硫氮ZHOU酮 胆固酮 

分 类 号：R972.6[医药卫生—药品]