双氯芬酸钠在GCE上的脉冲伏安测定  

Electroanalytical Studies of PharmaceuticalMolecules on a Glassy Carbon Electrode──Dif-ferential Pulse Voltammetric Determination of Di-clofenac Sodium

作　　者：杨运发[1] 师宏新[1] 

机构地区：[1]中国科学院长春应用化学研究所

出　　处：《分析试验室》1995年第4期5-7,共3页Chinese Journal of Analysis Laboratory

摘　　要：本文用线性扫描伏安法、脉冲伏安法、循环伏安法对新型非甾体抗炎镇痛药双氯芬酸钠在玻碳电极上的伏安行为进行了研究，发现在０．１ｍｏｌ／Ｌ氯化钾溶液中於＋０．７４Ｖ左右，产生一灵敏的氧化峰可用于定量。用本法测定制剂不需分离即可直接测定，相对标准偏差为１．９％（ｎ＝１０），平均回收率为９９．２％，测定下限达０．０５μｇ／ｍＬ。并对电极反应机理进行了初步探讨。The voltammetric behaviour of a newnon-steroidal anti-inflammatory analgesicdrug diclofenac sodium (DS) was investigat-ed by linear-sweep,differential-pulse,cyclicvoltammetry at a glassy carbon electrode. Ina medium of 0.1 mol/L KCl,DS shows awell defined anodic peak.The method hasbeen used for the direct determination of DSin tablets.The relative standard deviation(n=10)is 1.9%。Its recovery is in therange from 98%to 102%。The detectionlimit is 0. 05μg/mL.The mechanism of theelectrode reaction has been proposed.

关 键 词：双氯芬酸钠 玻碳电极 脉冲伏安测定 

分 类 号：O625.636[理学—有机化学] O657.14[理学—化学]