2GyX射线照射诱发小鼠精子发生各阶段的染色体畸变及显性致死突变  

STUDIES ON SPERM CHROMOSOME ABERRATIONS AND DOMINANT LETHALITY INDUCED BY 2 Gy OF X-RAYS AT DIFFERENT STAGES OF SPERMATOGENESIS IN MICE

作　　者：孙淑清[1] 姜杰[1] 王彬[1] 王献理[1] 

机构地区：[1]白求恩医科大学放射医学研究所

出　　处：《辐射防护》1995年第1期56-58,共3页Radiation Protection

摘　　要：本文用受精卵染色体分析技术和显性致死突变试验，观察电离辐射诱发遗传物质损伤效应。两种方法检测结果均表明：小鼠受２ＧｙＸ射线一次全身均匀照射，所诱发的精子染色体畸变和显性致死突变，都随着生精细胞向成熟精子发育过程而增加，两种实验结果呈正相关（ｒ＝０．８１４０），说明电离辐射诱发的染色体畸变是造成显性致死效应的主要贡献。同时也提示评价电离辐射近期遗传危害时更应重视精母细胞以后阶段受照时的遗传效应。The induction of chrornosome aberrations in fertilized eggs and dominant lethalmutations was examined in mice after a single whole-body exposure to 2.0 Gy X-rays at different stages of spermatogenesis by using an in vitro fertilization technique and a dominantlethal mutation examination,respectively.The results show that the incidences of body chromosome aberrations and dominant lethal mutations increased with the development of spermcells.Similar results have been obtained by those two methods and thus strongly suggest thatanalysis of chromosome aberrations in sperm cells after the stage of sermatocyte may be especially important for assessing the genetic effects of radiation.

关 键 词：电离辐射 精子 染色体 畸变 显性致死 突变 

分 类 号：Q345.22[生物学—遗传学]