电离辐射对人皮肤成纤维细胞中超氧阴离子自由基浓度和超氧化物歧化酶与组织蛋白酶D活力的影响  

RADIATION EFFECTS ON THE CONCENTRATION OF SOD AND CATHEPSIN D ACTIVITIES IN CULTURED SKIN FIBROBLASTS

作　　者：乐敏[1] 刘莉[1] 王荷英 何介薇[1] 

机构地区：[1]上海医科大学放射医学研究所

出　　处：《辐射研究与辐射工艺学报》1995年第4期243-245,共3页Journal of Radiation Research and Radiation Processing

摘　　要：６０Ｃｏγ射线１０～４０Ｇｙ照射正常人皮肤成纤维细胞，１ｈ后，细胞释放超氧阴离子自由基（Ｏ２）量显著增高，其增高与照射剂量呈正相关。细胞超氧化物歧化酶（ＳＯＤ）活力明显下降，且与照射剂量呈负相关。组织蛋白酶Ｄ活力显著增高，其增高与照射剂量呈正相关。在辐照０～４０Ｇｙ范围内，细胞释放Ｏ２量与细胞ＳＯＤ活力是负相关，而细胞释放Ｏ２量与细胞组织蛋白酶Ｄ活力呈正相关。Human skin fibroblasts were irradiated with 60Co r-ray 10Gy￣40 Gy.After one hour,the concentration of) increased significantly, the activity of SOD in cultured fibroblasts decreased markedly, and the activity of cathepsin D increased significantly. These changes related with the dose.when the radiation dose with the range of 0￣40Gy,the range of 0￣40Gy,the concentration of 0 related with the Activity of SOD and cathepsin D in cultrued skin fibroblasts.

关 键 词：辐射效应 放射性皮肤溃疡 SOD 皮肤成纤维细胞 

分 类 号：R818.895[医药卫生—放射医学]