反式硫代环磷酰基硫脲的合成及性质研究  

Studies on the Syntheses and Biological Activties of trans-Cyclothiophosphorylthioureas

作　　者：邵瑞链[1] 杨光富 苗伟时[1] 李广仁[1] 

机构地区：[1]南开大学元素有机化学研究所

出　　处：《高等学校化学学报》1995年第3期391-394,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：采用反式２－异硫氰基－４－苯基－５，５－二甲基－２－硫代－１，３，２－二氧磷杂环己烷与不同胺的加成反应合成了１３个新型的反式环状硫代磷酸基硫脲衍生物。生物活性初步测试表明，部分化合物具有杀菌及植物生长调节活性。本文首次报道了２－氯－４－苯基－５，５－二甲基－２－硫代－１，３，２－二氧磷杂环己烷与硫氰酸钾反应的立体化学。Thirteen new trans- cyclothiophosphorylthiourea derivatives,R￣1R￣2NC(S) NHR￣3 (R￣1=H,alkyl;R￣2=alkyl, substituted plienyl;R￣3=4-phenyl-5,5-dimethyl-2-sulfo-1,3,2dioxaphosplioranyl),were synthesized by the addition reaction of frans-2-isothiocyano-4plienyl-5,5-dimethyl-2-sulfo-1,3,2-dioxaphosphorinane to various amines respectively and their structure were confirmed by means of elemental analysis,￣1H NMR and IR. The biological activities of all new compounds were tedsted preliminarily and the results indicate that some compounds showed fungicidal activity and plant-growth reguiarity activity. In addition,the stereochemistry of the reaction between 2-chloro-4-phenyl-5,5-dimethyl-2-sulfo-1,3,2-dioxaphosphorinane and potassium thiocyanate was reported for the first time.

关 键 词：硫脲 立体化学 环状 硫代磷酰基 

分 类 号：O623.543[理学—有机化学]