水溶性金属卟啉肿瘤靶向磁共振成像造影剂的研究  

Studies on Water-Soluble Metalloporphyrins as Tumor Targeting Magnetic Resonance Imaging Contrast Agents

作　　者：罗毅[1] 梅二文[1] 卓仁禧[1] 

机构地区：[1]北京大学化学系,武汉大学分析测试科学系,武汉大学化学系

出　　处：《高等学校化学学报》1995年第10期1629-1632,共4页Chemical Journal of Chinese Universities

基　　金：国家"863"计划

摘　　要：利用显微荧光－阿达玛变换三维图像分析研究了Ｃｕ－ＴＳＰＰ、Ｍｎ－ＴＳＰＰ、Ｃｕ－ＴＭＡＰ、Ｍｎ－ＴＭＡＰ４种水溶性金属卟啉从细胞间质进入肿瘤细胞内的富集过程。对金属卟啉的自旋－晶格弛豫性能（Ｒ_１）的研究结果表明：Ｍｎ（Ⅱ）卟啉配合物的Ｒ_１值比Ｇｄ－ＤＴＰＡ提高了１．５～２倍。The development of nuclear magnetic resonance imaging technique has provided a noninvasive method for in vivo research in biological systems.Compounds which affect the relaxation time could provide additional contrast for NMR images and are potentially useful in a clinical setting.Synthesis of targeting MRI contrast agents for specific tissue and organs is the most attractive field in the recent MRI studies.In this work,four water-soluble metalloporphyrins,Cu(Ⅱ)-TSPP,Mn(Ⅱ)-TSPP.Cu(Ⅱ)-TMAP,Mn(Ⅲ)-TMAP Were synthesized and their structures were confirmed by UV,IR,1H NMR and elemental analysis.Targeting to S180 tumor cells of these water-soluble porphyrins was studied in vitro by microscope fluorescence-Hadamard transform three-dimensional image analysis.The spin-lattice relaxivity(R1)of Mn(Ⅱ)-porphyrin chelate is 1.5-2 times larger than that of Gd-DTPA.

关 键 词：金属卟啉 肿瘤 造影剂 MRI 磁共振诊断 

分 类 号：R981.1[医药卫生—药品] R814.43[医药卫生—药学]